News

BlaisePascalChair

Danny Reinberg has been awarded an International Blaise Pascal Chair to the Institut Curie-Centre de Recherche Université Paris, France.
He will be on Sabbatical for 2017 through early 2018.
The Blaise Chair, established in 1996 by the Government of the Île-de-France Region for internationally acclaimed foreign scientists in all disciplines. A scientific committee annually selects the most outstanding candidates from all over the world. Since its inception a number of famous scientists were the Blaise Pascal Chair laureates: Gérard Debreu (UC Berkeley, 1983 Nobel Prize in Economics), Ahmed Zewail (Caltech, 1999 Nobel Prize in Chemistry), Igor Mel’čuk (University of Montreal, the world leading researcher in linguistics), George Smoot (LBL, 2006 Nobel Prize in experimental Astrophysics), Robert Langlands (UBC, 1996 Wolf Prize, one of the most influential mathematicians of the 20th century), outstanding theoretical physicists Gabriele Veneziano (CERN/College de France), Alexander Zamolodchikov (Rutgers), and others.

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New grant from the Making Headway Foundation titled
“Novel Targeting of an Epigenetic Signature in Diffuse Instrinsic Pontine Gliomas”

HeadwayGrant


New Honor for Graduate Student Jeffrey Granat.
He has been named 2017 Vilcek Medical Scientist Training Program (MSTP) Scholar.
This is a merit-based scholarship that supports students for two years during their graduate school training.


Latest publications on pub med.

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New Papers

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An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants.

Yan, H., Opachaloemphan, C., Mancini, G., Yang, H., Gallitto, M., Miejnek J., Leibholz, A., Haight, K., Ghaninia, M., Huo, L., Perry, M., Slone, J., Zhou, X., Traficante, M., Penick, C.A., Dolezal, K., Gokhale, K., Stevens, K., Fetter-Pruneda, I., Bonasio, R., Zwiebel, L.J., Berger, S.L., Liebig, J., Reinberg, D. and Desplan, C. (2017). Cell Aug10;170(4):736-747.
PMID: 28802043.

Allosteric Activation Dictates PRC2 Activity Independent of its Recruitment to Chromatin.

Lee, C.H., Yu, J.R., Kumar, S. Yin, Y.,LeRoy, G., Bhanu, N., Kaneko, S., Garcia, B.A., Hamilton, A.D. and Reinberg, D. (2018). Mol. Cell, Apr13 pil: S1097-2765(18)30223-5. Epub ahead of print.
PMID: 29681499.

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.

Lee, C.H., Holder, M., Grau, D., Saldaña-Meyer, R., Yu, J.R., Ganai, R.A., Zhang, J., Wang, M., LeRoy, G., Dobenecker, M.W., Reinberg, D. and Armache, K.J. (2018). Mol. Cell Apr13 pil:S1097-2765(18)30222-3.
PMID: 29681498.

Capturing the onset of PRC2-mediated repressive domain formation.
Oksuz O., Narendra V., Lee C., Descostes N., LeRoy G., Raviram R., Blumenberg L., Karch K., Rocha P.P., Garcia B,A., Skok J.A., and Reinberg D. (2018). Mol. Cell (in press).

Link: https://www.biorxiv.org/content/early/2018/02/27/272989

GenesAndDevelopment

CTCF-mediated topological boundaries during development foster appropriate gene regulation.

Narendra V, Bulajić M, Dekker J, Mazzoni EO, Reinberg D
Genes Dev. 2016 Dec 15;30(24):2657-2662. doi: 10.1101/gad.288324.116.
PMID: 28087711

Chromatin Starts to Come Clean.
Tu S, LeRoy G, Reinberg D.
Mol Cell. 2016 Nov 3;64(3):439-441. doi: 10.1016/j.molcel.2016.10.022.
PMID: 27814489
Co-repressor CBFA2T2 regulates pluripotency and germline development.
Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D.
Nature. 2016 Jun 8;534(7607):387-90. doi: 10.1038/nature18004. PMID: 27281218
> Read More


Recently Published
Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.
Krishnan S, Smits AH, Vermeulen M, Reinberg D.
Mol Cell. 2017 Jul 26. pii: S1097-2765(17)30502-6. doi: 10.1016/j.molcel.2017.07.008. [Epub ahead of print]
PMID:28781233
Cell-logo
An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants.
Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, Leibholz A, Haight K, Ghaninia M, Huo L, Perry M, Slone J, Zhou X, Traficante M, Penick CA, Dolezal K, Gokhale K, Stevens K, Fetter-Pruneda I, Bonasio R, Zwiebel LJ, Berger SL, Liebig J, Reinberg D, Desplan C.
Cell. 2017 Aug 10;170(4):736-747.e9. doi: 10.1016/j.cell. 2017.06.051.
PMID:28802043
Cell-logo
The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants.
Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R.
Cell. 2017 Aug 10;170(4):748-759.e12. doi: 10.1016/j.cell.2017.07.014.
PMID:28802044

Manuscript Review:

Capturing the onset of epigenetic regulation.

Oksuz, O., Narendra, V., Lee, C-H., Descostes, N., LeRoy, G., Raviram, R., Karch, K., Rocha, P., Garcia, B., Skok, J. and Reinberg, D.
Nature 2017


 

Hyundai-Hope-ON-Wheels

New Hyundai Scholar Grant from Hyundai Hope on Wheels titled:
“Novel epigenetic strategies to therapeutically target pediatric high-grade glioma”


Heike’s Birthday at The Bierhaus.

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Postdoctoral Fellow Rais Ahmed Ganai has been awarded two fellowships from Sweden.
The Vetenskapsrådet and The Swedish Society for Medical Research. The start date is July 1, 2017 and is for 3 years, two years in the U.S. and a year in Sweden. The project he will be working on is “PRC2 dynamics during differentiation”

Stafford

Postdoctoral Fellow James Stafford has been awarded an NIH Fellowship that starts February, 2017 for 3 years.
This is a Career transition award through the National Institute on Alcohol Abuse and Alcoholism
Title: “AUTS2 and the chromatin dynamics of alcohol use disorders”

Havva

Graduate Student Havva Kara Ortabozhoyun has been awarded an NIH Fellowship that starts June, 2017 for 3 years.
This is a National Research Service Award through the Eunice Kennedy Shriver National Institute of Child Health and Human Development
Title: “Identification of factors that affect the insulator function of CTCF”

 


Jia Ray

Postdoctoral Fellow Jia-Ray Yu has been awarded an American Cancer Society Fellowship to start July, 2017 for 3 years.
His application by the DNA Mechanisms in Cancer Peer Review Committee was rated “Outstanding”.
Title: “Dissecting the Role of EZH2/PRC2 in Metastatic Melanoma”

 

Shenjiang

Congratulations to Shengjiang Tu -
Research Scientist, Surrozen, Inc. of South San Francisco