Scientific Journals – Dr. Danny Reinberg Laboratory

Insulin signaling in the long-lived reproductive caste of ants.

Yan H, Opachaloemphan C, Carmona-Aldana F, Mancini G, Mlejnek J, Descostes N, Sieriebriennikov B, Leibholz A, Zhou X, Ding L, Traficante M, Desplan C, Reinberg D.

Science. 2022 Sep 2;377(6610):1092-1099. doi: 10.1126/science.abm8767. Epub 2022 Sep 1.
PMID: 36048960

Inheritance of repressed chromatin domains during S phase requires the histone chaperone NPM1.

Escobar TM, Yu JR, Liu S, Lucero K, Vasilyev N, Nudler E, Reinberg D. Sci Adv. 2022 Apr 29;8(17):eabm3945. doi: 10.1126/sciadv.abm3945. Epub 2022 Apr 27.

PMID: 35476441
Free PMC article.

CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters.

Ortabozkoyun H, Huang PY, Cho H, Narendra V, LeRoy G, Gonzalez-Buendia E, Skok JA, Tsirigos A, Mazzoni EO, Reinberg D. Nat Genet. 2022 Feb;54(2):202-212. doi: 10.1038/s41588-021-01008-5. Epub 2022 Feb 10.

PMID: 35145304
Free PMC article.

NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.

Liu S, Aldinger KA, Cheng CV, Kiyama T, Dave M, McNamara HK, Zhao W, Stafford JM, Descostes N, Lee P, Caraffi SG, Ivanovski I, Errichiello E, Zweier C, Zuffardi O, Schneider M, Papavasiliou AS, Perry MS, Humberson J, Cho MT, Weber A, Swale A, Badea TC, Mao CA, Garavelli L, Dobyns WB, Reinberg D. Mol Cell. 2021 Nov 18;81(22):4757. doi: 10.1016/j.molcel.2021.10.023.

PMID: 34798045
No abstract available.

NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.

PMID: 34637754

The H3K36me2 writer-reader dependency in H3K27M-DIPG.

Yu JR, LeRoy G, Bready D, Frenster JD, Saldaña-Meyer R, Jin Y, Descostes N, Stafford JM, Placantonakis DG, Reinberg D. Sci Adv. 2021 Jul 14;7(29):eabg7444. doi: 10.1126/sciadv.abg7444. Print 2021 Jul.

PMID: 34261657
Free PMC article.

A molecular toolkit for superorganisms.

Sieriebriennikov B, Reinberg D, Desplan C. Trends Genet. 2021 Sep;37(9):846-859. doi: 10.1016/j.tig.2021.05.005. Epub 2021 Jun 8.

PMID: 34116864
Free PMC article. Review.

Reversible plasticity in brain size, behaviour and physiology characterizes caste transitions in a socially flexible ant (Harpegnathos saltator).

Penick CA, Ghaninia M, Haight KL, Opachaloemphan C, Yan H, Reinberg D, Liebig J. Proc Biol Sci. 2021 Apr 14;288(1948):20210141. doi: 10.1098/rspb.2021.0141. Epub 2021 Apr 14.

PMID: 33849311
Free PMC article.

Early behavioral and molecular events leading to caste switching in the ant Harpegnathos.

Opachaloemphan C, Mancini G, Konstantinides N, Parikh A, Mlejnek J, Yan H, Reinberg D, Desplan C. Genes Dev. 2021 Mar 1;35(5-6):410-424. doi: 10.1101/gad.343699.120. Epub 2021 Feb 18.

PMID: 33602869
Free PMC article.

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.

Grau D, Zhang Y, Lee CH, Valencia-Sánchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ. Nat Commun. 2021 Jan 29;12(1):714. doi: 10.1038/s41467-020-20775-z.

PMID: 33514705
Free PMC article.

Parental nucleosome segregation and the inheritance of cellular identity.

Escobar TM, Loyola A, Reinberg D. Nat Rev Genet. 2021 Jun;22(6):379-392. doi: 10.1038/s41576-020-00312-w. Epub 2021 Jan 26.

PMID: 33500558
Free PMC article. Review.

The missing linker: emerging trends for H1 variant-specific functions.

Prendergast L, Reinberg D. Genes Dev. 2021 Jan 1;35(1-2):40-58. doi: 10.1101/gad.344531.120.

PMID: 33397728
Free PMC article. Review.

Evolution, developmental expression and function of odorant receptors in insects.

Yan H, Jafari S, Pask G, Zhou X, Reinberg D, Desplan C. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1):jeb208215. doi: 10.1242/jeb.208215.

PMID: 32034042
Free PMC article. Review.

Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication.

Escobar TM, Oksuz O, Saldaña-Meyer R, Descostes N, Bonasio R, Reinberg D. Cell. 2019 Oct 31;179(4):953-963.e11. doi: 10.1016/j.cell.2019.10.009.

PMID: 31675501
Free PMC article.

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.

LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai RA, Kara HO, Yu JR, Lee CH, Stafford J, Shilatifard A, Reinberg D. Sci Adv. 2019 Oct 2;5(10):eaay3068. doi: 10.1126/sciadv.aay3068. eCollection 2019 Oct.

PMID: 31616795
Free PMC article.

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Saldaña-Meyer R, Rodriguez-Hernaez J, Escobar T, Nishana M, Jácome-López K, Nora EP, Bruneau BG, Tsirigos A, Furlan-Magaril M, Skok J, Reinberg D. Mol Cell. 2019 Nov 7;76(3):412-422.e5. doi: 10.1016/j.molcel.2019.08.015. Epub 2019 Sep 12.

PMID: 31522988
Free PMC article.

Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF.

Hansen AS, Hsieh TS, Cattoglio C, Pustova I, Saldaña-Meyer R, Reinberg D, Darzacq X, Tjian R. Mol Cell. 2019 Nov 7;76(3):395-411.e13. doi: 10.1016/j.molcel.2019.07.039. Epub 2019 Sep 12.

PMID: 31522987
Free PMC article.

A Method to Study de novo Formation of Chromatin Domains.

Oksuz O, Reinberg D. J Vis Exp. 2019 Aug 23;(150):10.3791/60039. doi: 10.3791/60039.

PMID: 31498316
Free PMC article.

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.

Lee CH, Yu JR, Granat J, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D. Genes Dev. 2019 Oct 1;33(19-20):1428-1440. doi: 10.1101/gad.328773.119. Epub 2019 Sep 5.

PMID: 31488577
Free PMC article.

PRC2 is high maintenance.

Yu JR, Lee CH, Oksuz O, Stafford JM, Reinberg D.
Genes Dev. 2019 Aug 1;33(15-16):903-935. doi: 10.1101/gad.325050.119. Epub 2019 May 23. Review.
PMID: 31123062
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Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.

Stafford JM, Lee CH, Voigt P, Descostes N, Saldaña-Meyer R, Yu JR, Leroy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin NS, Placantonakis DG, Karajannis MA, Snuderl M, Ueberheide B, Reinberg D.
Sci Adv. 2018 Oct 31;4(10):eaau5935. doi: 10.1126/sciadv.aau5935. eCollection 2018 Oct.
PMID: 30402543
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Recent Advances in Behavioral (Epi)Genetics in Eusocial Insects.

Opachaloemphan C, Yan H, Leibholz A, Desplan C, Reinberg D.
Annu Rev Genet. 2018 Nov 23;52:489-510. doi: 10.1146/annurev-genet-120116-024456. Epub 2018 Sep 12. Review.

PMID: 30208294
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Antennal Olfactory Physiology and Behavior of Males of the Ponerine Ant Harpegnathos saltator.

Ghaninia M, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J.
J Chem Ecol. 2018 Nov;44(11):999-1007. doi: 10.1007/s10886-018-1013-6. Epub 2018 Sep 7.
PMID: 30191433
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Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level.

Chen P, Dong L, Hu M, Wang YZ, Xiao X, Zhao Z, Yan J, Wang PY, Reinberg D, Li M, Li W, Li G.
Mol Cell. 2018 Jul 19;71(2):284-293.e4. doi: 10.1016/j.molcel.2018.06.020.
PMID: 30029006
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Chromatin domains rich in inheritance.

Reinberg D, Vales LD.
Science. 2018 Jul 6;361(6397):33-34. doi: 10.1126/science.aat7871. No abstract available.
PMID: 29976815
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Capturing the Onset of PRC2-Mediated Repressive Domain Formation.

Oksuz O, Narendra V, Lee CH, Descostes N, LeRoy G, Raviram R, Blumenberg L, Karch K, Rocha PP, Garcia BA, Skok JA, Reinberg D.
Mol Cell. 2018 Jun 21;70(6):1149-1162.e5. doi: 10.1016/j.molcel.2018.05.023.

PMID: 29932905
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Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin.

Lee CH, Yu JR, Kumar S, Jin Y, LeRoy G, Bhanu N, Kaneko S, Garcia BA, Hamilton AD, Reinberg D.
Mol Cell. 2018 May 3;70(3):422-434.e6. doi: 10.1016/j.molcel.2018.03.020. Epub 2018 Apr 19.
PMID: 29681499
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Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.

Lee CH, Holder M, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ.
Mol Cell. 2018 May 3;70(3):435-448.e5. doi: 10.1016/j.molcel.2018.03.019. Epub 2018 Apr 19.
PMID: 29681498
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Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA, Placantonakis DG.
Cell Rep. 2017 Oct 31;21(5):1267-1280. doi: 10.1016/j.celrep.2017.10.009.
PMID: 29091765
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